Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11192133 | 0.90 | CYP1A2 (0.36) | HTTTSHRMAPTKMT2ALMNA | |
| SCHEMBL11055179 | 0.90 | ALDH1A1 (0.48) | ALDH1A1MAPTKMT2ALMNAHPGD | |
| SCHEMBL11280868 | 0.89 | IDH1 (0.38) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11286642 | 0.88 | HTT (0.55) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11282636 | 0.85 | HTT (0.38) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11434842 | 0.85 | CYP1A2 (0.33) | HTTALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL11059296 | 0.85 | RAPGEF4 (0.42) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL10854903 | 0.85 | HTT (0.41) | HTTTSHRALDH1A1MAPTKMT2A | |
| SCHEMBL11052411 | 0.84 | HTT (0.41) | HTTTSHRALDH1A1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL11414461 | 0.84 | RAPGEF4 (0.41) | HTTTSHRALDH1A1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4283555-A | Amidinoureas | WILLIAM H. RORER, INC. (US) | 1981-08-11 | — | — | US | disclosed |
| US-4216229-A | 1-AMIDINO-3-PHENYLUREAS | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4216230-A | Method for alleviating hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-08-05 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4183956-A | Method for treating gastrointestinal spasms, gastrointestinal hyperacidity and hypertensive disorders with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-01-15 | — | — | US | disclosed |
| US-4150154-A | GASTROINTESTINAL ANTISPASMODICS | WILLIAM H. RORER, INC. (US) | 1979-04-17 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |