Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12745718 | 0.87 | HSD11B1 (0.46) | HSD11B1OPRM1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL5768239 | 0.84 | CYP2C9 (0.50) | HSD11B1OPRM1CYP2C9APPCYP3A4 | |
| SCHEMBL19358562 | 0.83 | HSD11B1 (0.40) | HSD11B1HDAC1CYP2C9PDE4APDE4B | |
| SCHEMBL1447883 | 0.82 | MEN1 (0.55) | HSD11B1OPRM1SMN1; SMN2CYP2C9ALDH1A1 | |
| SCHEMBL11044295 | 0.82 | HSD11B1 (0.52) | HSD11B1OPRM1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL11047897 | 0.82 | OPRM1 (0.47) | HSD11B1OPRM1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL8179850 | 0.80 | F10 (0.47) | MAPTSMN1; SMN2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL11050761 | 0.79 | OPRM1 (0.67) | OPRM1ALDH1A1 | |
| SCHEMBL15765668 | 0.78 | OPRM1 (0.63) | HSD11B1OPRM1SMN1; SMN2KMT2A | |
| SCHEMBL11044721 | 0.78 | CYP2C9 (0.42) | HSD11B1OPRM1HDAC1CYP2C9APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |