Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20601546 | 0.89 | OPRM1 (0.52) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL16897591 | 0.86 | OPRM1 (0.47) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL16699935 | 0.85 | OPRM1 (0.43) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL31117190 | 0.85 | ALDH1A1 (0.53) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL4944766 | 0.85 | ALDH1A1 (0.57) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL16287573 | 0.84 | KCNA3 (0.48) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL15348097 | 0.84 | PDE4A (0.39) | OPRM1ALDH1A1PDE4APDE4BPDE4C | |
| SCHEMBL21726313 | 0.84 | ALDH1A1 (0.56) | OPRM1SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL5765569 | 0.84 | MEN1 (0.50) | OPRM1MEN1KMT2AOPRK1L3MBTL1 | |
| SCHEMBL11050761 | 0.84 | OPRM1 (0.67) | OPRM1ALDH1A1OPRK1ADRA1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035902-B1 | 1-(4-ARYL-CYCLOHEXYL)PIPERIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-10-31 | — | — | EP | disclosed |
| US-4329353-A | ANTIEMETIC AND NEUROLEPTIC AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1982-05-11 | — | — | US | disclosed |
| EP-0035902-A1 | 1-(4-Aryl-cyclohexyl)piperidine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-09-16 | — | — | EP | disclosed |