SCHEMBL11287131

SCHEMBL11287131

Cc1ccc(Oc2ccc(C(O)CCNC(C)(C)C)cc2Oc2ccc(C)cc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.37
ALDH1A1 P00352 2/20 0.36
MAPT P10636 1/20 0.36
HIF1A Q16665 2/20 0.36
HTR2A P28223 1/20 0.36
SLC6A4 P31645 1/20 0.36
KCNH2 Q12809 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
ADRB2 P07550 3/20 0.35
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
ADRB1 P08588 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
TBXA2R P21731 2/20 0.34
AR P10275 1/20 0.34
GAA P10253 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10897411 0.87 ADRB2 (0.48) ACHEALDH1A1MAPTHIF1ALMNA
Hydrochloric Acid SCHEMBL11286988 0.86 TDP1 (0.49) ALDH1A1MAPTHIF1ALMNACYP3A4
SCHEMBL11290751 0.84 SLC22A3 (0.41) ALDH1A1MAPTHIF1ALMNACYP3A4
SCHEMBL11283334 0.82 PMP22 (0.50) HIF1ALMNAADRB2CYP1A2CYP2D6
SCHEMBL11278278 0.79 ACHE (0.42) ACHEALDH1A1MAPTHIF1ALMNA
Hydrochloric Acid SCHEMBL11278267 0.78 TDP1 (0.42) ACHEALDH1A1MAPTHIF1AADRB2
SCHEMBL11419377 0.78 ACHE (0.40) ACHEALDH1A1MAPTHIF1AHTR2A
SCHEMBL11282273 0.78 PMP22 (0.46) HIF1ALMNAADRB2CYP1A2CYP2D6
SCHEMBL11525219 0.78 HIF1A (0.51) ALDH1A1MAPTHIF1AHTR2ASLC6A4
SCHEMBL11284670 0.78 SCN1A (0.37) ACHEALDH1A1MAPTHIF1AHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4336400-A BRONCHODILATOR AGENTS, CARDIOVASCULAR STIMULANTS STERLING DRUG INC. (US) 1982-06-22 US disclosed
US-4138581-A BRONCHODILATOR AGENTS, ADRENERGIC STIMULANTS STERLING DRUGS INC. (US) 1979-02-06 US disclosed