SLC22A3

Solute carrier family 22 member 3 · O75751 · SLC22A3 on Sugi Atlas →

30,929 patent compounds predicted against SLC22A3, 25,711 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL166140	1.00	7/20
Phenylguanidine (SCHEMBL467577)	1.00	6/20
SCHEMBL164098	0.56	6/20
SCHEMBL247052	0.52	6/20
Iodide (SCHEMBL82245)	0.42	3/20
Famotidine (SCHEMBL973)	1.00	2/20
Imipramine (SCHEMBL34282)	1.00	2/20
Desipramine (SCHEMBL34384)	1.00	2/20
Famotidine (SCHEMBL39237)	1.00	2/20
Famotidine (SCHEMBL458654)	1.00	2/20
Imipramine (SCHEMBL41765)	0.97	2/20
Imipramine (SCHEMBL41766)	0.97	2/20
Desipramine (SCHEMBL41992)	0.97	2/20
Desipramine (SCHEMBL41993)	0.94	2/20
11Beta-Hydroxyprogesterone (SCHEMBL572275)	0.79	2/20
Desoxycorticosterone (SCHEMBL4065)	0.78	2/20
Desoxycorticosterone (SCHEMBL4066)	0.78	2/20
Quinaldine Blue (SCHEMBL58012)	0.77	2/20
Quinaldine Blue (SCHEMBL466982)	0.74	2/20
Famotidine (SCHEMBL188452)	0.67	2/20

Clinical trials — most relevant to SLC22A3 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Genetic Basis for Variation in the Renal Elimination of Metformin	PHASE4	COMPLETED
Applying Proton Pump Inhibitor to Prevent and Treat Acute Fluctuating Hearing Loss in Patients With SLC26A4 Mutation	PHASE2/PHASE3	UNKNOWN
Treatment of Ectopic Calcification in Fahr's Disease or Syndrome	PHASE2	RECRUITING
Effect of, OAT3, on the Renal Secretion of Cefotaxime	PHASE1	COMPLETED
Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters	EARLY_PHASE1	COMPLETED
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer	EARLY_PHASE1	UNKNOWN
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy	nan	COMPLETED
Cancer and Hearing Loss Related in Children	nan	COMPLETED
SLC13A5 Deficiency Natural History Study - Remote Only	nan	ENROLLING_BY_INVITATION
Influence of OCTN2 Variants on Carnitine Status and Plasma Triglycerides	nan	COMPLETED
Impact of Polymorphisms of OAT1, OAT3, and OCT2 on Transportation of Potential Nephrotoxic Drugs	nan	COMPLETED
Clinical and Genetic Analysis of Enlarged Vestibular Aqueducts	nan	COMPLETED
Oxalate and Citrate in Humans - Response to Citrate	nan	RECRUITING
Study of ABCB1,SLC22A16 Drug Transporter Genes and Doxorubicin and Cyclophosphamide Toxicity in Brest Cancer Patient	nan	UNKNOWN
Bile Acid Effects in Fetal Arrhythmia Study	nan	UNKNOWN
Understanding Methotrexate Induced Gastrointestinal Intolerance in Juvenile Idiopathic Arthritis and Childhood Leukemia	nan	COMPLETED
Effect of SLC01B1 (rs2306283) Polymorphism on the Efficacy and Safety Profile of Atorvastatin in Pakistani Population	nan	COMPLETED
Autonomic Function in Patients With COPD	nan	COMPLETED
Gastrostomy-Biliary Diversion: Innovative Management for Bile Canalicular Transport Disorders	nan	UNKNOWN
Genetics of Hyperuricemia Therapy in Hmong	nan	COMPLETED
Cardiovascular Effects of Empagliflozine	nan	UNKNOWN
Coproporphyrine Isomers and Methotrexate Elimination	nan	COMPLETED
Gyrate Atrophy Ocular and Systemic Study	nan	ACTIVE_NOT_RECRUITING
Renal and Hepatic Clearance Following High-Dose Methotrexate in Childhood ALL	nan	COMPLETED
Impact of Genetics on Metformin Pharmacokinetics	nan	COMPLETED
Secondary Sclerosing Cholangitis in Critically Ill Patients	nan	ACTIVE_NOT_RECRUITING
SLC13A5 Deficiency Natural History Study - United States Only	nan	ENROLLING_BY_INVITATION
Role of the ATP7A Transporter in Ovarian Cancer	nan	COMPLETED
Demographic, Metabolic, and Genomic Description of Neonates With Severe Hyperbilirubinemia	nan	COMPLETED
Effect of Pharmacogenetics on Imatinib Plasma Level and Response	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SLC22A3 binder may also engage these)

Protein	Name	Similarity
O88446	—	0.999	O88446 →
O02713	—	0.994	O02713 →
Q9WTW5	—	0.993	Q9WTW5 →
Q8MJI6	—	0.993	Q8MJI6 →
Q9R0W2	—	0.993	Q9R0W2 →
Q5R5H7	—	0.991	Q5R5H7 →
O76082	—	0.990	O76082 →
SLC22A2	Solute carrier family 22 member 2	0.989	landscape →
SLC22A1	Solute carrier family 22 member 1	0.989	landscape →
O08966	—	0.989	O08966 →
Q863T6	—	0.988	Q863T6 →
Q91WU2	—	0.988	Q91WU2 →
O77504	—	0.987	O77504 →
A9CB25	—	0.987	A9CB25 →
Q9R141	—	0.987	Q9R141 →
SLC22A4	Solute carrier family 22 member 4	0.987	landscape →
O70577	—	0.986	O70577 →
A7MBE0	—	0.985	A7MBE0 →
Q9Z306	—	0.985	Q9Z306 →
B2GV36	—	0.985	B2GV36 →
Q9Z0E8	—	0.985	Q9Z0E8 →
Q63089	—	0.984	Q63089 →
Q9WTN6	—	0.982	Q9WTN6 →
O70594	—	0.982	O70594 →
Q9Y226	—	0.981	Q9Y226 →
Q961J5	—	0.981	Q961J5 →
Q9R1U7	—	0.979	Q9R1U7 →
O57379	—	0.979	O57379 →
Q17QN9	—	0.977	Q17QN9 →
SLC22A16	Solute carrier family 22 member 16	0.977	landscape →