Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.48 |
| ▸ | WNT3A | P56704 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | GABRP | O00591 | 2/20 | 0.46 |
| ▸ | GABRD | O14764 | 2/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11269374 | 0.79 | RAB9A (0.48) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL31651414 | 0.76 | KMT2A (0.65) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL10924639 | 0.73 | RAB9A (0.50) | KMT2AMEN1MAPTPOLBLMNA | |
| SCHEMBL3717752 | 0.73 | ADAM17 (0.68) | KMT2AMAPTADAM17CTNNB1WNT3A | |
| SCHEMBL15902100 | 0.72 | ADAM17 (0.67) | KMT2AMAPTADAM17CTNNB1WNT3A | |
| SCHEMBL11269287 | 0.72 | NPC1 (0.45) | KMT2AMEN1MAPTPOLBSMN1; SMN2 | |
| SCHEMBL11293448 | 0.72 | GSK3B (0.45) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11271153 | 0.71 | RAB9A (0.47) | KMT2AMEN1MAPTCYP1A2CYP3A4 | |
| SCHEMBL11271605 | 0.71 | RAB9A (0.40) | KMT2AMEN1MAPTCTNNB1WNT3A | |
| SCHEMBL4056357 | 0.70 | ADAM17 (0.68) | KMT2AMEN1MAPTADAM17CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044705-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |