Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALPG | P10696 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10924639 | 0.90 | RAB9A (0.50) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11271605 | 0.87 | RAB9A (0.40) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11271153 | 0.87 | RAB9A (0.47) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11269374 | 0.87 | RAB9A (0.48) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11278217 | 0.84 | GSK3B (0.43) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11274050 | 0.83 | MAPT (0.46) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11288872 | 0.80 | TRPA1 (0.38) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11291348 | 0.80 | CES2 (0.37) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11281594 | 0.75 | CDYL (0.44) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL11293448 | 0.74 | GSK3B (0.45) | NPC1RAB9AMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044704-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | claimed |
| EP-0044704-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |