Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11285441 | 0.85 | KDM4E (0.46) | KMT2AMAPK1TSHR | |
| SCHEMBL7387393 | 0.75 | KMT2A (0.50) | KMT2ATSHRCYP1A2GAACYP2C9 | |
| SCHEMBL11724685 | 0.72 | CYP1A2 (0.46) | KMT2AMAPK1TSHRLMNACYP1A2 | |
| SCHEMBL20148797 | 0.71 | FAAH (0.41) | TRPV1TSHRLMNACYP1A2HTR2C | |
| SCHEMBL9653024 | 0.70 | TRPV1 (0.42) | TRPV1GAAHTR1AHTR1DHTR1B | |
| SCHEMBL9653138 | 0.70 | HRH3 (0.40) | TRPV1HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL885034 | 0.69 | NOTUM (0.49) | NOTUMHTR2CHTR2B | |
| SCHEMBL16110071 | 0.69 | TRPV1 (0.40) | KMT2ATRPV1CYP1A2HTR1AHTR1D | |
| SCHEMBL424738 | 0.69 | NOTUM (0.47) | KMT2ATRPV1NOTUMHTR2CHTR2B | |
| SCHEMBL3600670 | 0.69 | TRPV1 (0.40) | KMT2ATRPV1CYP1A2HTR1AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |