Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | NR5A1 | Q13285 | 13/20 | 0.41 |
| ▸ | RORA | P35398 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287448 | 0.85 | KMT2A (0.46) | KMT2ATSHRMAPK1 | |
| SCHEMBL11599952 | 0.82 | KDM4E (0.42) | KDM4EALDH1A1MAPTHTTHPGD | |
| SCHEMBL11283090 | 0.75 | ADRB2 (0.48) | KDM4EALDH1A1MAPTHTTHPGD | |
| SCHEMBL27647162 | 0.71 | KDM4E (0.49) | KDM4EALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL11724685 | 0.71 | CYP1A2 (0.46) | KDM4EMEN1KMT2ATSHRMAPK1 | |
| SCHEMBL27939754 | 0.70 | KDM4E (0.48) | KDM4EALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL9653138 | 0.69 | HRH3 (0.40) | — | |
| SCHEMBL9644250 | 0.69 | LMNA (0.54) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL5124456 | 0.69 | TDP1 (0.55) | KDM4EALDH1A1MAPTHTTHPGD | |
| SCHEMBL19177326 | 0.68 | ESR2 (0.44) | KDM4EALDH1A1MAPTHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |