Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 1/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.51 |
| ▸ | CMA1 | P23946 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ESRRG | P62508 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7676183 | 0.89 | PRSS1 (0.63) | PRSS1CTSGCTRB1CMA1GAA | |
| SCHEMBL14636882 | 0.81 | HTT (0.55) | GPR139PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL11289084 | 0.80 | KMT2A (0.52) | GAANPC1MEN1KMT2ACSNK1D | |
| SCHEMBL7272796 | 0.79 | GPR139 (0.60) | GPR139GAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27419582 | 0.78 | GPR139 (0.55) | GPR139PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL23968027 | 0.77 | GPR139 (0.58) | GPR139GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL22330633 | 0.77 | GAA (0.55) | GPR139GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11489196 | 0.77 | POLB (0.56) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL10154034 | 0.76 | GPR139 (0.61) | GPR139GAASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7515133 | 0.76 | KDM4E (0.59) | GPR139GAASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006298-B1 | ANTI-INFLAMMATORY 1-PHENYL-2-AMINOETHANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF FOR TOPICAL USE, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-03-31 | — | — | EP | disclosed |