Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290931 | 0.86 | SIGMAR1 (0.51) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11284729 | 0.85 | SIGMAR1 (0.51) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11279990 | 0.82 | SIGMAR1 (0.47) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11288900 | 0.81 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11285221 | 0.81 | HTR2A (0.53) | ADRA2A | |
| Hydrochloric Acid SCHEMBL11293177 | 0.80 | HTR2A (0.52) | ADRA2A | |
| SCHEMBL11289002 | 0.80 | SIGMAR1 (0.60) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11286148 | 0.78 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11287225 | 0.77 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11222634 | 0.76 | DRD2 (0.46) | OPRM1LMNAADRA2ACYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |