Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 17/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11287225 | 0.87 | SIGMAR1 (0.57) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11279673 | 0.86 | SIGMAR1 (0.56) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11286129 | 0.86 | SIGMAR1 (0.58) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11288975 | 0.80 | SIGMAR1 (0.53) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11282321 | 0.80 | HTR2A (0.53) | ADRA2A | |
| Hydrochloric Acid SCHEMBL11282385 | 0.79 | HTR2A (0.52) | ADRA2ADRD1 | |
| SCHEMBL11281688 | 0.77 | SIGMAR1 (0.53) | SIGMAR1OPRM1KCNH2LMNACHRM2 | |
| SCHEMBL11236321 | 0.76 | DRD2 (0.46) | OPRM1LMNAADRA2ACYP2D6TSHR | |
| SCHEMBL11289006 | 0.76 | LMNA (0.39) | LMNATSHR | |
| SCHEMBL11290931 | 0.75 | SIGMAR1 (0.51) | SIGMAR1OPRM1KCNH2LMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353900-A | HYPOTENSIVE, ANTIARRHYTHMIA, CARDIOTONIC, VASODILATORS | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |