Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | PLAU | P00749 | 2/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
| ▸ | SMO | Q99835 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11289129 | 0.86 | MAPT (0.54) | MAPTL3MBTL1HSD11B1PLAUSRD5A2 | |
| SCHEMBL1515720 | 0.81 | MAPT (0.66) | MAPTL3MBTL1HSD11B1PLAUSRD5A2 | |
| SCHEMBL1515715 | 0.80 | L3MBTL1 (0.70) | MAPTL3MBTL1PLAUSRD5A2RAB9A | |
| SCHEMBL13577050 | 0.80 | MAPT (0.60) | MAPTL3MBTL1PLAUSRD5A2RAB9A | |
| SCHEMBL15100944 | 0.77 | MAPT (0.60) | MAPTL3MBTL1HSD11B1PLAUSRD5A2 | |
| SCHEMBL256731 | 0.77 | MAPT (0.60) | MAPTL3MBTL1HSD11B1PLAUSRD5A2 | |
| SCHEMBL1515818 | 0.77 | L3MBTL1 (0.65) | MAPTL3MBTL1PLAUSRD5A2RAB9A | |
| SCHEMBL11251033 | 0.75 | MAPT (0.50) | MAPTL3MBTL1RAB9AMEN1KMT2A | |
| SCHEMBL7129800 | 0.75 | MAPT (0.80) | MAPTL3MBTL1PLAUSRD5A2RAB9A | |
| SCHEMBL24800 | 0.75 | MAPT (0.73) | MAPTL3MBTL1PLAUSRD5A2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006298-B1 | ANTI-INFLAMMATORY 1-PHENYL-2-AMINOETHANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF FOR TOPICAL USE, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-03-31 | — | — | EP | disclosed |
| US-4303649-A | ANTIINFLAMMATORY AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-01 | — | — | US | disclosed |
| EP-0006298-A1 | Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-01-09 | — | — | EP | disclosed |