Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SMO | Q99835 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11289132 | 0.86 | MAPT (0.59) | MAPTL3MBTL1SMOPLAUSRD5A2 | |
| SCHEMBL1515710 | 0.81 | S1PR5 (0.59) | MAPTL3MBTL1SMOPLAUMAPK1 | |
| SCHEMBL28042412 | 0.79 | PLAU (0.46) | MAPTL3MBTL1PLAUMAPK1ALDH1A1 | |
| SCHEMBL3007072 | 0.77 | CA2 (0.55) | MAPTALDH1A1HIF1AKDM4ECYP3A4 | |
| SCHEMBL2599737 | 0.77 | PIK3CA (0.58) | MAPTL3MBTL1SMOPLAUMAPK1 | |
| SCHEMBL7349990 | 0.75 | CTNNB1 (0.41) | MAPTL3MBTL1SMOMAPK1GSK3B | |
| SCHEMBL7199268 | 0.75 | MAPT (0.67) | MAPTL3MBTL1SMOPLAUMAPK1 | |
| SCHEMBL24800 | 0.75 | MAPT (0.73) | MAPTL3MBTL1PLAUMAPK1GSK3B | |
| SCHEMBL3673844 | 0.74 | L3MBTL1 (0.49) | MAPTL3MBTL1SMOPLAUMAPK1 | |
| SCHEMBL3060994 | 0.74 | PLAU (0.60) | MAPTL3MBTL1SMOPLAUMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0006298-B1 | ANTI-INFLAMMATORY 1-PHENYL-2-AMINOETHANOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF FOR TOPICAL USE, AND PROCESSES FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-03-31 | — | — | EP | disclosed |
| US-4303649-A | ANTIINFLAMMATORY AGENTS | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-12-01 | — | — | US | disclosed |
| EP-0006298-A1 | Anti-inflammatory 1-phenyl-2-aminoethanol derivatives, pharmaceutical compositions thereof for topical use, and processes for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1980-01-09 | — | — | EP | disclosed |