Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 16/20 | 0.65 |
| ▸ | MAOA | P21397 | 15/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11066098 | 0.99 | MAOB (0.66) | MAOBMAOAPDE3BPDE3AHTR1A | |
| SCHEMBL10900191 | 0.95 | MAOB (0.67) | MAOBMAOAPDE3BPDE3AHTR1A | |
| SCHEMBL11287532 | 0.91 | MAOB (0.67) | MAOBMAOAPDE3BPDE3AHTR1A | |
| SCHEMBL16409766 | 0.87 | HDAC1 (0.68) | MAOBMAOAPDE3BPDE3AHDAC3 | |
| SCHEMBL16398839 | 0.85 | PDE3B (0.59) | MAOBMAOAPDE3BPDE3ADRD2 | |
| SCHEMBL11288012 | 0.85 | PDE3B (0.59) | MAOBMAOAPDE3BPDE3ADRD2 | |
| SCHEMBL16059342 | 0.85 | MAOB (0.67) | MAOBMAOADRD2 | |
| SCHEMBL6584817 | 0.84 | MAOB (0.67) | MAOBMAOAPDE3BPDE3AHTR1A | |
| SCHEMBL10898729 | 0.84 | MAOB (0.67) | MAOBMAOAPDE3BPDE3AHTR1A | |
| SCHEMBL11283546 | 0.84 | MAOA (0.67) | MAOBMAOAPDE3BPDE3AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |