Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.58 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27676700 | 0.84 | ALDH1A3 (0.54) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL427668 | 0.83 | MAPK1 (0.64) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL11287649 | 0.82 | KDM4E (0.55) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL11280001 | 0.82 | HPGD (0.52) | SMN1; SMN2MAPK1LMNAHTTKMT2A | |
| SCHEMBL10953569 | 0.78 | NOTUM (0.51) | SMN1; SMN2MAPTGAAAKR1C3LMNA | |
| SCHEMBL517732 | 0.74 | LMNA (0.52) | SMN1; SMN2MAPTMAPK1AKR1C3LMNA | |
| SCHEMBL23537930 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL12864867 | 0.74 | MAPT (0.64) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL13718469 | 0.74 | MAPT (0.64) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 | |
| SCHEMBL13826326 | 0.74 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTGAAALDH3A1ALDH1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059688-A1 | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use | CIBA-GEIGY AG (CH) | 1982-09-08 | — | — | EP | disclosed |