Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LGMN | Q99538 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.42 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424288 | 0.84 | ALDH1A1 (0.55) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL11289375 | 0.82 | SMN1; SMN2 (0.58) | ALDH1A1LMNASMN1; SMN2NPC1MAPT | |
| SCHEMBL11280001 | 0.81 | HPGD (0.52) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL4377045 | 0.78 | MAPT (0.71) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL31491393 | 0.78 | MAPT (0.71) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL28153718 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL10953569 | 0.77 | NOTUM (0.51) | KDM4EALDH1A1LMNASMN1; SMN2MAPT | |
| SCHEMBL2711166 | 0.76 | LGMN (0.74) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL3724717 | 0.75 | KDM4E (0.67) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 | |
| SCHEMBL2711594 | 0.75 | KDM4E (0.59) | KDM4EALDH1A1LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059688-A1 | Pyridazinones, method for their preparation, pharmaceutical compositions containing these compounds and their use | CIBA-GEIGY AG (CH) | 1982-09-08 | — | — | EP | disclosed |