Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11278098 | 0.88 | LMNA (0.64) | ALDH1A1SMN1; SMN2LMNADHODHGAA | |
| SCHEMBL6492363 | 0.87 | PTGDR2 (0.55) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL11159408 | 0.84 | MAPT (0.62) | MAPTKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL11289926 | 0.82 | DHODH (0.51) | MAPTALDH1A1LMNADHODHNPSR1 | |
| SCHEMBL11284116 | 0.81 | ALDH1A1 (0.50) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL11286855 | 0.81 | SMN1; SMN2 (0.54) | KDM4ENPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL9131445 | 0.79 | MAPT (0.44) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL3406390 | 0.77 | LMNA (0.41) | KDM4ERAB9AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL9750566 | 0.77 | CDC7 (0.51) | MAPTKDM4ENPC1RAB9ACASP3 | |
| SCHEMBL10237187 | 0.76 | SMN1; SMN2 (0.57) | MAPTKDM4ENPC1RAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336389-A | 2-Substituted-4-aryl-5-thiazolecarboxylic acids and their derivatives as safening agents | MONSANTO COMPANY (US) | 1982-06-22 | — | — | US | disclosed |