Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11601503 | 0.97 | DRD2 (0.52) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11287055 | 0.92 | ADRB2 (0.47) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11292144 | 0.86 | ADRB2 (0.52) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11479869 | 0.84 | ADRB2 (0.50) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11281273 | 0.83 | ADRB2 (0.49) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL18072426 | 0.81 | ADRB2 (0.54) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL11319220 | 0.81 | ADRB1 (0.51) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL16409781 | 0.81 | HDAC1 (0.50) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL30335516 | 0.80 | ADRB1 (0.50) | DRD2ADRB2ADRB1HTR1AOPRK1 | |
| SCHEMBL1764193 | 0.80 | ADRB2 (0.57) | DRD2ADRB2ADRB1HTR1AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313947-A | TREATMENT OF BLOOD DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1982-02-02 | — | — | US | disclosed |
| US-4216220-A | Platelet aggregation inhibiting 2-oxyindoles, their compositions and method of use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1980-08-05 | — | — | US | disclosed |
| US-4070470-A | BENCYCLOAMIDE DERIVATIVES | OTSUKA PHARMACEUTICAL CO., LTD. (JA) | 1978-01-24 | — | — | US | disclosed |