Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.72 |
| ▸ | PGR | P06401 | 6/20 | 0.72 |
| ▸ | AR | P10275 | 6/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.71 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.65 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.65 |
| ▸ | MMP1 | P03956 | 5/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595110 | 0.92 | NR3C1 (0.72) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11424701 | 0.92 | NR3C1 (0.80) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11125211 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL93664 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11875376 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11125210 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL3164036 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11600203 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL11600201 | 0.92 | NR3C1 (0.85) | NR3C1PGRARCYP3A4HIF1A | |
| SCHEMBL10598748 | 0.91 | PGR (0.73) | NR3C1PGRARCYP3A4HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000742-B1 | CORTICOIDS-17-ALKYLCARBONATES, PROCESS FOR THEIR PREPARATION AND PREPARATIONS CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-12 | — | — | EP | disclosed |
| US-4242334-A | ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| EP-0000742-A1 | Corticoids-17-alkylcarbonates, process for their preparation and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-02-21 | — | — | EP | disclosed |