Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.43 |
| ▸ | ALPL | P05186 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11260137 | 0.70 | KCNH2 (0.57) | ADRA2CKCNH2 | |
| Nitric Acid SCHEMBL10833077 | 0.70 | ADRA2C (0.51) | HIF1ATSHRADRA2CKCNH2MEN1 | |
| Nitric Acid SCHEMBL10469484 | 0.65 | HIF1A (0.40) | HIF1ATSHRCYP2D6CYP2C19MEN1 | |
| Nitric Acid SCHEMBL11847913 | 0.65 | CYP3A4 (0.64) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| SCHEMBL6213236 | 0.65 | KCNH2 (0.47) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| Nitric Acid SCHEMBL10469482 | 0.65 | CYP3A4 (0.46) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| SCHEMBL4817509 | 0.64 | ADRA2C (1.00) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| SCHEMBL4664253 | 0.64 | ADRA2C (1.00) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| SCHEMBL4664843 | 0.64 | ADRA2C (1.00) | HIF1ATSHRCYP2D6CYP2C19ADRA2C | |
| SCHEMBL29846165 | 0.64 | ADRA2C (1.00) | HIF1ATSHRCYP2D6CYP2C19ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049913-A2 | New ethenylimidazole derivatives, processes for their preparation and pharmaceutical compositions containing them; intermediates, useful in their preparation and a process for the preparation thereof | GIST-BROCADES N.V. (NL) | 1982-04-21 | — | — | EP | disclosed |