Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.36 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 6/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | USP2 | O75604 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL10469482 | 0.70 | CYP3A4 (0.46) | HIF1ATSHRCYP2D6CYP2C19GABRA2 | |
| Nitric Acid SCHEMBL11289809 | 0.65 | HIF1A (0.50) | HIF1ATSHRCYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL5705666 | 0.63 | KMT2A (0.43) | TSHRALDH1A1PKMLMNAMAPK1 | |
| Nitric Acid SCHEMBL11263278 | 0.62 | HIF1A (0.47) | HIF1ATSHRCYP2D6CYP2C19ALDH1A1 | |
| Nitric Acid SCHEMBL10876696 | 0.62 | OGG1 (0.53) | HIF1ATSHRCYP2D6CYP2C19ALDH1A1 | |
| Nitric Acid SCHEMBL10338641 | 0.62 | TSHR (0.37) | HIF1ATSHRCYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL28197166 | 0.62 | CYP2D6 (0.43) | HIF1ATSHRCYP2D6CYP2C19GABRA2 | |
| SCHEMBL8047156 | 0.62 | HCAR1 (0.42) | CYP2C19GABRA2GABRB2HCAR1LMNA | |
| SCHEMBL11532281 | 0.62 | CYP19A1 (0.36) | HIF1ATSHRCYP2D6CYP2C19MAPK1 | |
| Nitric Acid SCHEMBL11271762 | 0.61 | HIF1A (0.62) | HIF1ATSHRCYP2D6CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4965277-A | Fungicides | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1990-10-23 | — | — | US | disclosed |