Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.60 |
| ▸ | IDO1 | P14902 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.60 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | FYN | P06241 | 3/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4664843 | 1.00 | ADRA2C (1.00) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4817509 | 1.00 | ADRA2C (1.00) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL30256070 | 1.00 | ADRA2C (1.00) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL29846165 | 1.00 | ADRA2C (1.00) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL9366325 | 0.87 | ADRA2C (0.76) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL10925864 | 0.86 | ADRA2C (0.76) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL11263656 | 0.86 | ADRA2C (0.76) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL11304305 | 0.85 | ADRA2C (0.74) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL11617815 | 0.85 | ADRA2C (0.74) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL11278424 | 0.85 | ADRA2C (0.74) | ADRA2CCYP2C9CYP3A4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101955462-A | Fenticonazole nitrate, preparation of levorotatory form and dextrorotatory form and application of levorotatory form in preparing antifungal medicaments | QIAOGEN ZOU | 2011-01-26 | — | — | CN | claimed |
| CN-101955462-B | Fenticonazole nitrate, preparation of levorotatory form and dextrorotatory form and application of levorotatory form in preparing antifungal medicaments | QIAOGEN ZOU | 2012-10-31 | — | — | CN | disclosed |
| CN-101955462-A | Fenticonazole nitrate, preparation of levorotatory form and dextrorotatory form and application of levorotatory form in preparing antifungal medicaments | QIAOGEN ZOU | 2011-01-26 | — | — | CN | disclosed |
| US-7323433-B2 | R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole | FERRER INTERNACIONAL, S.A. (ES) | 2008-01-29 | — | — | US | disclosed |
| US-7323433-B2 | R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole | FERRER INTERNACIONAL, S.A. (ES) | 2008-01-29 | — | — | US | disclosed |
| US-7323433-B2 | R-(-)-1-[2-(7-chlorobenzo[b]thiopen-3-yl-methoxy)-2-(2,4-dichlorophenyl)-ethyl]-1H-imidazole | FERRER INTERNACIONAL, S.A. (ES) | 2008-01-29 | — | — | US | disclosed |
| EP-1474422-B1 | R-(-)-1-¬2-(7-CHLOROBENZO-¬B -THIOPHEN-3-Yl-METHOXY)-2-(2,4-DICHLOROPHENYL)ETHYL -1H-IMIDAZOLE | FERRER INT (ES) | 2008-01-02 | — | — | EP | disclosed |
| US-6916813-B2 | (1-phenyl-2-heteoaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase | BRISTOL-MYERS SQUIBB CO. (US) | 2005-07-12 | — | — | US | disclosed |
| US-20050065201-A1 | R-(-)-1-[2-(7- chlorobenzo[b]thiophen-3-yl- methoxy)-2-(2,4-dichlorophenyl)- ethyl]-1H-imidazole | FERRER INTERNACIONAL S.A. (ES) | 2005-03-24 | — | — | US | disclosed |
| EP-1474422-A1 | R− (−) −1− 2− &lpar ;7−CHLOROBENZO i b /i THIOPHEN−3 &minus ;YL− METHOXY) −2− (2,4−DICHLOROPHENYL) −ETHYL −1 i H /i −IMID AZOLE | FERRER INTERNACIONAL, S.A. (ES) | 2004-11-10 | — | — | EP | disclosed |
| US-20040039033-A1 | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase | BRISTOL-MYERS SQUIBB COMPANY | 2004-02-26 | — | — | US | disclosed |
| WO-2003068770-A1 | R- (-) -1- [2- (7-CHLOROBENZO [b] THIOPHEN-3 -YL- METHOXY) -2- (2,4-DICHLOROPHENYL) -ETHYL] -1H-IMIDAZOLE | FERRER INTERNACIONAL S.A. (ES) | 2003-08-21 | — | — | WO | disclosed |
| EP-1143798-A4 | CHIRAL IMIDAZOLE FUNGICIDAL COMPOSITIONS AND METHODS FOR THEIR USE | CELGENE CORP (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1143798-A1 | CHIRAL IMIDAZOLE FUNGICIDAL COMPOSITIONS AND METHODS FOR THEIR USE | CELGENE CORPORATION (US) | 2001-10-17 | — | — | EP | disclosed |
| US-6207695-B1 | INHIBITING GROWTH OF FUNGUS IN ASSOCIATION WITH A PLANT COMPRISING APPLYING TO THE LOCUS OF A PLANT A FUNGICIDALLY EFFECTIVE AMOUNT OF THE (S)-ENANTIOMER OF 1-(2-(2,4-DICHLOROPHENYL)-2-(2-PROPENYLOXY)ETHYL)-1H-IMIDAZOLE | CELGENE CORPORATION | 2001-03-27 | — | — | US | disclosed |
| WO-2000038521-A1 | CHIRAL IMIDAZOLE FUNGICIDAL COMPOSITIONS AND METHODS FOR THEIR USE | CELGENE CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |
| EP-0430194-A2 | Aryl-alkyl-azoles substituted with many times unsaturated groups, process for their preparation and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-06-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065201-A1 | R-(-)-1-[2-(7- chlorobenzo[b]thiophen-3-yl- methoxy)-2-(2,4-dichlorophenyl)- ethyl]-1H-imidazole | IRF3, IRF2BP2, ARG2 | ADRA2C 1250/4885CYP2C9 2477/4885CYP3A4 1071/4885 |
| US-20040039033-A1 | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial F1F0 ATP hydrolase | ATP5F1A, ATP5ME, ATP5F1D | ADRA2C 783/4885CYP2C9 595/4885CYP3A4 991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.