Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545389 | 0.84 | SLC6A4 (0.36) | SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL11295572 | 0.84 | LMNA (0.37) | KMT2A | |
| SCHEMBL11294422 | 0.82 | PDK2 (0.36) | KMT2A | |
| SCHEMBL11292074 | 0.82 | SLC6A4 (0.41) | SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL11290081 | 0.81 | IDO1 (0.32) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11289410 | 0.81 | — | — | |
| SCHEMBL11289879 | 0.81 | KMT2A (0.33) | SLC6A4OPRM1KMT2A | |
| SCHEMBL11290458 | 0.81 | APOBEC3A (0.39) | — | |
| SCHEMBL11290059 | 0.81 | RIPK1 (0.30) | — | |
| SCHEMBL31452460 | 0.81 | SLC6A4 (0.34) | SLC6A2SLC6A4SLC6A3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000825-B1 | GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kabi AB (SE) | 1982-04-14 | — | — | EP | disclosed |
| US-4218472-A | USED AS DECONGESANT, HYPOTENSIVE AGENT, VASOCONSTRICTOR, ANTI-RESERPINE AGENT, TREATING INCONTINENCE | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000825-A1 | Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |