Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290081 | 0.94 | IDO1 (0.32) | IDO1 | |
| SCHEMBL11294673 | 0.92 | SLC6A4 (0.34) | IDO1 | |
| SCHEMBL11291041 | 0.79 | IDO1 (0.34) | IDO1TAAR1HTR3ATSHRNFKB1 | |
| SCHEMBL11295572 | 0.78 | LMNA (0.37) | — | |
| SCHEMBL11289410 | 0.78 | — | — | |
| SCHEMBL31452460 | 0.75 | SLC6A4 (0.34) | TAAR1TSHRNFKB1HIF1AKDM4E | |
| SCHEMBL11288858 | 0.75 | SLC6A4 (0.34) | TAAR1TSHRNFKB1HIF1AKDM4E | |
| SCHEMBL11290059 | 0.75 | RIPK1 (0.30) | — | |
| SCHEMBL11290458 | 0.75 | APOBEC3A (0.39) | — | |
| SCHEMBL11349725 | 0.74 | ADRB2 (0.41) | TSHRNFKB1HIF1AKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000825-B1 | GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kabi AB (SE) | 1982-04-14 | — | — | EP | disclosed |
| US-4218472-A | USED AS DECONGESANT, HYPOTENSIVE AGENT, VASOCONSTRICTOR, ANTI-RESERPINE AGENT, TREATING INCONTINENCE | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000825-A1 | Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |