Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11289808 | 0.80 | HDAC4 (0.37) | HDAC4AKR1C1PDK2SMN1; SMN2KMT2A | |
| SCHEMBL11290184 | 0.79 | KDM4E (0.38) | HDAC4AKR1C1PDK2SMN1; SMN2SLC6A3 | |
| SCHEMBL11287867 | 0.74 | PTPN1 (0.37) | HDAC4AKR1C1PDK2SMN1; SMN2KMT2A | |
| SCHEMBL11542300 | 0.72 | HRH3 (0.33) | HDAC4AKR1C1PDK2SMN1; SMN2SLC6A3 | |
| SCHEMBL12991020 | 0.69 | OPRM1 (0.44) | HRH3 | |
| SCHEMBL12991141 | 0.69 | OPRM1 (0.44) | HRH3 | |
| SCHEMBL11462365 | 0.67 | — | — | |
| SCHEMBL11544999 | 0.67 | AKR1C1 (0.37) | HDAC4AKR1C1PDK2SMN1; SMN2MEN1 | |
| SCHEMBL12991119 | 0.67 | OPRL1 (0.47) | — | |
| SCHEMBL11549304 | 0.66 | SLC6A3 (0.31) | SLC6A3SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000825-B1 | GEMINALLY DISUBSTITUTED INDENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Kabi AB (SE) | 1982-04-14 | — | — | EP | disclosed |
| US-4218472-A | USED AS DECONGESANT, HYPOTENSIVE AGENT, VASOCONSTRICTOR, ANTI-RESERPINE AGENT, TREATING INCONTINENCE | AB KABI (SE) | 1980-08-19 | — | — | US | disclosed |
| EP-0000825-A1 | Geminally disubstituted indene derivatives, processes for their preparation and pharmaceutical compositions containing them | Kabi AB (SE) | 1979-02-21 | — | — | EP | disclosed |