Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | PPM1B | O75688 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29263995 | 1.00 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL20104022 | 0.87 | TLR4 (0.43) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL12441829 | 0.87 | TLR4 (0.43) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL14228339 | 0.82 | — | — | |
| SCHEMBL1134463 | 0.78 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL28641852 | 0.78 | — | — | |
| SCHEMBL1027514 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL1027513 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL1027512 | 0.77 | ALDH1A1 (0.37) | ALDH1A1MEN1KMT2AGAAKDM4E | |
| SCHEMBL1027541 | 0.74 | PPM1B (0.41) | ALDH1A1GAAMAPTPPM1BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283020-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI Pharmaceuticals, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| EP-2178563-A2 | COMBINATION ANTI-CANCER THERAPY COMPRISING AN INHIBITOR OF BOTH MTORC1 AND MTORC2 | OSI Pharmaceuticals, Inc. (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009143051-A1 | SUBSTITUTED IMIDAZOPYR-AND IMIDAZOTRI-AZINES | OSI PHARMACEUTICALS, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| WO-2009008992-A2 | COMBINATION ANTI-CANCER THERAPY COMPRISING AN INHIBITOR OF BOTH MTORC1 AND MT0RC2 | OSI PHARMACEUTICALS INC. (US) | 2009-01-15 | — | — | WO | disclosed |
| EP-1951724-A2 | FUSED BICYCLIC mTOR INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007061737-A2 | FUSED BICYCLIC mTOR INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2007-05-31 | — | — | WO | disclosed |