Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.48 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.48 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8344485 | 0.90 | RHEB (0.49) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL11293385 | 0.88 | PKN1 (0.62) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL28267390 | 0.78 | CHEK2 (0.61) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL19994470 | 0.76 | RHEB (0.59) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL8412123 | 0.76 | RHEB (0.59) | PKN1PKN2RHEBMETAP2METAP1 | |
| SCHEMBL1842081 | 0.76 | RHEB (0.59) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL1842216 | 0.76 | PKN1 (0.59) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL3333407 | 0.76 | RHEB (0.68) | PKN1PKN2RHEBKDM4ENPC1 | |
| SCHEMBL4387879 | 0.75 | IMPDH2 (0.46) | PKN1PKN2RHEBMETAP2METAP1 | |
| SCHEMBL20982583 | 0.74 | RHEB (0.70) | PKN1PKN2RHEBKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009163-B1 | Substituted bisbenzimidazole derivatives, their preparation and antiprotozoic and antiviral agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |
| EP-0009163-A2 | Substituted bisbenzimidazole derivatives, their preparation and antiprotozoic and antiviral agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-04-02 | — | — | EP | disclosed |
| US-4156778-A | Substituted bis-benzimidazolyl compounds; preparation and use thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-29 | — | — | US | disclosed |