Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKN1 | Q16512 | 1/20 | 0.62 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.62 |
| ▸ | METAP2 | P50579 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 1/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 4/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.49 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | RHEB | Q15382 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11293382 | 0.88 | PKN1 (0.48) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL20982510 | 0.82 | PKN1 (0.82) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL8344485 | 0.79 | RHEB (0.49) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL18764054 | 0.78 | CHEK2 (0.78) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL14816640 | 0.76 | PKN1 (0.72) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL3341423 | 0.76 | PKN1 (0.72) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL1253278 | 0.75 | PKN1 (0.58) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL23563056 | 0.74 | PKN1 (0.68) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL20550741 | 0.74 | ALOX5 (0.64) | PKN1PKN2METAP2METAP1CHEK2 | |
| SCHEMBL10188885 | 0.74 | PKN1 (0.57) | PKN1PKN2METAP2METAP1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009163-B1 | Substituted bisbenzimidazole derivatives, their preparation and antiprotozoic and antiviral agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-06-30 | — | — | EP | disclosed |
| EP-0009163-A2 | Substituted bisbenzimidazole derivatives, their preparation and antiprotozoic and antiviral agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-04-02 | — | — | EP | disclosed |