Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727876 | 0.80 | MMP2 (0.41) | MAPTGAAALDH1A1POLBTDP1 | |
| SCHEMBL2934781 | 0.79 | ALDH1A1 (0.48) | MAPTGAAALDH1A1MAPK13MAPK12 | |
| SCHEMBL1451727 | 0.79 | AKR1C3 (0.53) | MAPTGAAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9712668 | 0.78 | ALDH1A1 (0.46) | MAPTGAAALDH1A1MAPK13MAPK12 | |
| SCHEMBL10783053 | 0.78 | ALDH1A1 (0.46) | MAPTALDH1A1MAPK14POLBTDP1 | |
| SCHEMBL10388386 | 0.78 | ALDH1A1 (0.46) | MAPTGAAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL5063031 | 0.76 | ALDH1A1 (0.46) | MAPTGAAALDH1A1TDP1L3MBTL1 | |
| SCHEMBL8979738 | 0.76 | CYP3A4 (0.38) | MAPTGAAALDH1A1POLBTDP1 | |
| SCHEMBL11292197 | 0.76 | RECQL (0.51) | MAPTGAAALDH1A1MAPK13MAPK12 | |
| SCHEMBL17559557 | 0.75 | ALDH1A1 (0.43) | ALDH1A1TDP1L3MBTL1ATMSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797875-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | Pharmacyclics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013101600-A1 | CINNAMIC ACID HYDROXYAMIDES AS INHIBITORS OF HISTONE DEACETYLASE 8 | PHARMACYCLICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
| EP-0014454-B1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 2-BENZAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-09-22 | — | — | EP | disclosed |