Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727876 | 0.83 | MMP2 (0.41) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| SCHEMBL11516367 | 0.78 | KDM4E (0.45) | CYP3A4ALOX15CASP7SMN1; SMN2MAPT | |
| SCHEMBL10482945 | 0.78 | KDM4E (0.45) | CYP3A4MAPTHSD17B10TSHRPOLB | |
| SCHEMBL10822473 | 0.77 | PARP1 (0.35) | CYP3A4MAPTHSD17B10TSHRPOLB | |
| SCHEMBL3980869 | 0.77 | CES2 (0.37) | CYP3A4ALOX15SMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8013581 | 0.76 | GAA (0.32) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| SCHEMBL11294754 | 0.76 | MAPT (0.53) | CYP3A4ALOX15CASP1CASP7SMN1; SMN2 | |
| SCHEMBL6790765 | 0.76 | ALDH1A1 (0.52) | ALOX15CASP1CASP7MAPTHSD17B10 | |
| SCHEMBL28249598 | 0.72 | GRM6 (0.38) | ALOX15SMN1; SMN2MAPTHSD17B10TSHR | |
| SCHEMBL27749672 | 0.72 | ALDH1A1 (0.56) | CYP3A4ALOX15SMN1; SMN2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | ABBVIE INC. (US) | 2020-02-11 | — | — | US | claimed |
| EP-3350187-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Inc. (US) | 2018-07-25 | — | — | EP | claimed |
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | claimed |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-16 | — | — | US | claimed |
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | ABBVIE INC. (US) | 2020-02-11 | — | — | US | disclosed |
| EP-3350187-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Inc. (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | disclosed |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-03-16 | — | — | US | disclosed |
| CN-104961723-A | 1H-benzimidazole-4-carboxamides substituted with a quaternary carbon at the 2-position are potent PARP inhibitors | ABBOTT LAB | 2015-10-07 | — | — | CN | disclosed |
| CN-101155797-B | 1H-benzimidazole-4-carboxamide compounds substituted at the 2-position with a quaternary carbon atom are potent PARP inhibitors | ABBOTT LAB | 2015-04-29 | — | — | CN | disclosed |
| CN-104302640-A | 3,5-diaminopyrazole kinase inhibitors | AXIKIN PHARMACEUTICALS INC | 2015-01-21 | — | — | CN | disclosed |
| US-5482831-A | Wash composition containing signal stop reagent, test kit and method of use with peroxidase-labeled specific binding ligand | JOHNSON & JOHNSON CLINICAL DIAGNOSTICS, INC. (US) | 1996-01-09 | — | — | US | disclosed |
| US-5460946-A | Diagnostic test kit and specific binding assay using modulator of signal resulting from peroxidase label | EASTMAN KODAK COMPANY (US) | 1995-10-24 | — | — | US | disclosed |
| US-5252457-A | Using acyl hydrazines as stopping agent; Streptococcus A detection; colorimetric, fluorescent or chemiluminescent signal | EASTMAN KODAK COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0537826-A1 | Diagnostic test kit and specific binding assay using a peroxidase label and a modulator of signal | EASTMAN KODAK COMPANY (US) | 1993-04-21 | — | — | EP | disclosed |
| EP-0537825-A1 | Wash composition containing signal stop reagent, test kit and method of use with peroxidase-labeled specific binding ligand | Johnson & Johnson Clinical Diagnostics, Inc. (US) | 1993-04-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | GABRB1, GABBR1, GABBR2 | CYP3A4 192/4885ALOX15 2514/4885CASP1 4496/4885 |
| US-20170073353-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | GABRB1, GABBR1, GABBR2 | CYP3A4 192/4885ALOX15 2514/4885CASP1 4496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.