Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.37 |
| ▸ | ERN1 | O75460 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710208 | 0.83 | KDM4E (0.44) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL24685164 | 0.81 | ALDH1A1 (0.43) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL30029431 | 0.81 | ALDH1A1 (0.43) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL29192341 | 0.81 | ALDH1A1 (0.43) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL30430258 | 0.80 | ALDH1A1 (0.50) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1085042 | 0.80 | ALDH1A1 (0.50) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL25343847 | 0.78 | KDM4E (0.54) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL24685165 | 0.77 | KDM4E (0.38) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL14660349 | 0.77 | ALDH1A1 (0.43) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL1987390 | 0.77 | KDM4E (0.42) | KDM4ECYP3A4ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140155389-A1 | BICYCLIC INHIBITORS OF ALK | ABBVIE INC. (US) | 2014-06-05 | — | — | US | disclosed |
| EP-2665724-A1 | BICYCLIC INHIBITORS OF ALK | AbbVie Inc. (US) | 2013-11-27 | — | — | EP | disclosed |
| WO-2012097682-A1 | BICYCLIC INHIBITORS OF ALK | ABBOTT LABORATORIES (US) | 2012-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140155389-A1 | BICYCLIC INHIBITORS OF ALK | ALK, ABL1, BOD1L1 | KDM4E 838/4885CYP3A4 1376/4885CYP1A2 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.