Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710208 | 0.84 | KDM4E (0.44) | KDM4ESMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL30430258 | 0.84 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL1085042 | 0.84 | ALDH1A1 (0.50) | KDM4ESMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL8606526 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL29592465 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL12701205 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL14660349 | 0.81 | ALDH1A1 (0.43) | KDM4ESMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL21349700 | 0.81 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1ABL1NQO2 | |
| SCHEMBL19991019 | 0.81 | KDM4E (0.42) | KDM4ESMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL110643 | 0.81 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1ABL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4472739-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2024-12-11 | — | — | EP | disclosed |
| WO-2023148129-A1 | IMIDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-10 | — | — | WO | disclosed |