Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.70 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 2/20 | 0.63 |
| ▸ | GABRP | O00591 | 3/20 | 0.62 |
| ▸ | GABRD | O14764 | 3/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.62 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.62 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.62 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.62 |
| ▸ | GABRE | P78334 | 3/20 | 0.62 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.62 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.62 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.62 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060147 | 0.95 | POLB (0.73) | POLBNPC1RAB9AIGF1RGABRP | |
| SCHEMBL30712063 | 0.89 | NPC1 (0.71) | POLBNPC1RAB9AIGF1RGABRP | |
| SCHEMBL16596188 | 0.87 | HDAC1 (0.71) | GABRA1GABRB2ALOX5MAPT | |
| SCHEMBL13649743 | 0.84 | TRPV1 (0.56) | POLBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13649611 | 0.84 | TRPV1 (0.56) | POLBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL13644772 | 0.84 | TRPV1 (0.56) | POLBGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30712070 | 0.84 | GABRP (0.72) | POLBNPC1RAB9AIGF1RGABRP | |
| SCHEMBL1130211 | 0.83 | NR4A2 (0.53) | POLB | |
| SCHEMBL20647966 | 0.82 | MAPT (0.53) | POLBGABRA1GABRB2MAPTMEN1 | |
| SCHEMBL10244787 | 0.81 | HDAC1 (0.67) | POLBNPC1GABRA1GABRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282735-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | Signum Biosciences, Inc. (US) | 2011-02-16 | — | — | EP | claimed |
| WO-2009132051-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | SIGNUM BIOSCIENCES, INC. (US) | 2009-10-29 | — | — | WO | claimed |
| US-10583119-B2 | Compounds, compositions and methods for making the same | SIGNUM BIOSCIENCES, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-20170266161-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | SIGNUM BIOSCIENCES, INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-9486441-B2 | Compounds, compositions and methods for making the same | SIGNUM BIOSCIENCES, INC. (US) | 2016-11-08 | — | — | US | disclosed |
| EP-2282735-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | Signum Biosciences, Inc. (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009132051-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | SIGNUM BIOSCIENCES, INC. (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20090264496-A1 | Compounds, Compositions and Methods for Making the Same | SIGNUM BIOSCIENCES, INC. | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264496-A1 | Compounds, Compositions and Methods for Making the Same | PPP2CA, PPP4C, PPP6C | POLB 608/4885NPC1 4184/4885RAB9A 3562/4885 |
| US-20170266161-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MAKING THE SAME | PPP2CA, PPP4C, PPP6C | POLB 608/4885NPC1 4184/4885RAB9A 3562/4885 |
| US-10583119-B2 | Compounds, compositions and methods for making the same | PPP2CA, PPP4C, PPP6C | POLB 608/4885NPC1 4184/4885RAB9A 3562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.