Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11299997 | 0.98 | LMNA (0.70) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11289986 | 0.94 | MAPT (0.65) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL4731655 | 0.91 | LMNA (0.72) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11268901 | 0.91 | LMNA (0.72) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11264433 | 0.91 | LMNA (0.68) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11296975 | 0.88 | LMNA (0.54) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11289940 | 0.86 | LMNA (0.57) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11268845 | 0.85 | LMNA (0.61) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11293789 | 0.85 | LMNA (0.52) | LMNAMAPTABCB11MAPK1POLB | |
| SCHEMBL11293008 | 0.84 | ABCB11 (0.61) | LMNAMAPTABCB11MAPK1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337267-A | HYPOKETONEMIC, HYPOGLYCEMIC, ANTIDIABETIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1982-06-29 | — | — | US | disclosed |