Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 8/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.51 |
| ▸ | CMA1 | P23946 | 2/20 | 0.49 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | CTSG | P08311 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | DPP3 | Q9NY33 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL683813 | 0.94 | ACE (0.57) | ACEACE2CMA1ELANECTSG | |
| SCHEMBL11271619 | 0.94 | ACE (0.57) | ACEACE2CMA1ELANECTSG | |
| SCHEMBL683814 | 0.89 | SLC6A2 (0.56) | ACEACE2SLC6A2OPRM1 | |
| SCHEMBL683506 | 0.87 | ACE (0.54) | ACEACE2CMA1SLC6A2DPP3 | |
| SCHEMBL11278066 | 0.87 | ACE (0.54) | ACEACE2CMA1SLC6A2DPP3 | |
| SCHEMBL11459782 | 0.87 | ACE (0.54) | ACEACE2CMA1SLC6A2DPP3 | |
| SCHEMBL683121 | 0.87 | ACE (0.49) | ACEACE2CMA1SLC6A2OPRM1 | |
| Alacepril SCHEMBL34559 | 0.87 | ACE (0.55) | ACEACE2CMA1SLC6A2OPRM1 | |
| Alacepril SCHEMBL11460465 | 0.87 | ACE (0.55) | ACEACE2CMA1SLC6A2OPRM1 | |
| Alacepril SCHEMBL3204613 | 0.87 | ACE (0.55) | ACEACE2CMA1SLC6A2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007477-B1 | 1-(3-MERCAPTO-2-METHYLPROPANOYL)PROLYL AMINO ACID DERIVATIVES AND SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS | Dainippon Pharmaceutical Co., Ltd. (JP) | 1982-04-28 | — | — | EP | disclosed |
| US-4248883-A | ANTIHYPERTENSION AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1981-02-03 | — | — | US | disclosed |