Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | MIF | P14174 | 1/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.53 |
| ▸ | VCP | P55072 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16743643 | 0.86 | HTT (0.54) | KDM4EMIFHTTLMNAMMP13 | |
| SCHEMBL97659 | 0.79 | NPC1 (0.54) | KDM4ELMNAMMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL10691068 | 0.77 | NPC1 (0.55) | KDM4EHTTLMNAMMP13SMN1; SMN2 | |
| SCHEMBL14028274 | 0.77 | HTT (0.60) | KDM4EHTTLMNAMMP13SMN1; SMN2 | |
| SCHEMBL29935019 | 0.77 | SMN1; SMN2 (0.57) | HTTLMNAMMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL99151 | 0.76 | NPC1 (0.54) | KDM4ELMNAMMP13SMN1; SMN2ALDH1A1 | |
| SCHEMBL10913886 | 0.76 | KDM4E (0.50) | KDM4EMIFHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5521119 | 0.75 | MAOB (0.45) | KDM4EMIFHTTLMNAMMP13 | |
| SCHEMBL10411023 | 0.73 | HTT (0.70) | KDM4EHTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6637213 | 0.73 | TP53 (0.56) | KDM4ELMNAMMP13SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337335-A | Transition metal salt complexes of polyamino organic compounds | SCHERING CORPORATION (US) | 1982-06-29 | — | — | US | disclosed |
| US-4230847-A | Aminoglycoside antibiotic compounds | SCHERING CORPORATION (US) | 1980-10-28 | — | — | US | disclosed |