Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2 | P11137 | 6/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.46 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11557335 | 0.93 | MAP2 (0.54) | MAP2ALOX15GPR17MDM4MDM2 | |
| SCHEMBL11300082 | 0.90 | MAP2 (0.62) | MAP2GPR35PTGS2 | |
| SCHEMBL11305292 | 0.83 | MAP2 (0.54) | MAP2PTGS2 | |
| SCHEMBL11298671 | 0.83 | MAP2 (0.67) | MAP2PTGS2 | |
| SCHEMBL11267254 | 0.82 | METAP2 (0.41) | GPR35ALOX15MDM4MDM2 | |
| SCHEMBL11304667 | 0.79 | MEN1 (0.40) | MAP2GPR35 | |
| SCHEMBL11551753 | 0.79 | MAP2 (0.48) | MAP2GPR35ALOX15GPR17MDM4 | |
| SCHEMBL11307889 | 0.79 | MAP2 (0.52) | MAP2GPR35 | |
| SCHEMBL11298754 | 0.78 | MAP2 (0.39) | MAP2GPR35 | |
| SCHEMBL11307329 | 0.77 | MAP2 (0.41) | MAP2GPR35GPR17PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4255442-A | 2-[(Methylsulfinyl)]-3-phenylindoles | SCHERING CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |
| EP-0000972-A2 | 2-Substituted-3-phenylindoles, their preparation, and pharmaceutical compositions containing them | Technobiotic Ltd. (CH) | 1979-03-07 | — | — | EP | disclosed |