Tetrahydrocortisone

Tetrahydrocortisone

SCHEMBL11299557

C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.ClC(Cl)=C(Cl)Cl

nearest known ligand 0.74

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 4/20 0.74
CYP3A4 P08684 4/20 0.73
GABRA1 P14867 5/20 0.55
GABRB2 P47870 5/20 0.55
GABRG2 P18507 3/20 0.55
GABRB3 P28472 3/20 0.55
GABRA2 P47869 3/20 0.55
CYP2C9 P11712 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
GLA P06280 1/20 0.55
HSD17B10 Q99714 6/20 0.52
LMNA P02545 2/20 0.52
ALDH1A1 P00352 2/20 0.52
NR3C1 P04150 2/20 0.52
SERPINA6 P08185 2/20 0.52
CYP2D6 P10635 1/20 0.52
TSHR P16473 1/20 0.52
SHBG P04278 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrocortisone SCHEMBL21296378 0.97 G6PD (0.76) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL193711 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL4111245 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1184192 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5610354 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1332665 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1184193 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL320596 0.96 G6PD (0.74) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5139991 0.96 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL6461669 0.96 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104487428-A Epoxidation process SCIENT DESIGN CO 2015-04-01 CN disclosed
CN-101356142-B Process for the production of pentafluoroethane MEXICHEM AMANCO HOLDING SA 2012-11-07 CN disclosed
CN-100519529-C Vapor phase catalytic chlorination of beta-picoline DOW AGROSCIENCES LLC (US) 2009-07-29 CN disclosed
CN-101356142-A Process for the production of pentafluoroethane INEOS FLUOR HOLDINGS LTD (GB) 2009-01-28 CN disclosed
CN-101356140-A Process for preparing dichlorotrifluoroethane INEOS FLUOR HOLDINGS LTD (GB) 2009-01-28 CN disclosed
CN-101084248-A Macroporous plastic bead material ROEHM GMBH (DE) 2007-12-05 CN disclosed
CN-1934085-A Vapor phase catalytic chlorination of beta-picoline DOW AGROSCIENCES LLC (US) 2007-03-21 CN disclosed
CN-1066699-C Single stage process for producing hydrofluorocarbons from perchloroethylene ALLIED SIGNAL INC (US) 2001-06-06 CN disclosed
CN-1051782-C Resin composition for producing foamed hot-molded article and molded article produced from the resin composition FOSECO INT (GB) 2000-04-26 CN disclosed
CN-1244570-A Method for lowering benzene content in petroleum fraction and isomerizing alkanodrocarbon INST FRANCAIS DU PETROLE (FR) 2000-02-16 CN disclosed
CN-1048519-C Isomerization catalyst INST FRANCAIS DU PETROLE (FR) 2000-01-19 CN disclosed
CN-1149286-A Single stage process for producing hydrofluorocarbons from perchloroethylene ALLIED SIGNAL INC (US) 1997-05-07 CN disclosed
CN-1111673-A method for reducing benzene content in petroleum INST FRANCAIS DU PETROLE (FR) 1995-11-15 CN disclosed
CN-1084863-A Resin composition for producing foamed hot-molded article, molded article produced from the resin composition, and use thereof for metal casting FOSECO INT (GB) 1994-04-06 CN disclosed
EP-0044595-A1 Process for the preparation of copolymers of ethylene with at least one other 1-alkene STAMICARBON B.V. (NL) 1982-01-27 EP disclosed
EP-0044119-A2 Process for the preparation of copolymers of ethylene with at least one other 1-alkene STAMICARBON B.V. (NL) 1982-01-20 EP disclosed