Tetrahydrocortisone

Tetrahydrocortisone

SCHEMBL320596

C[C@]12CC[C@@H](O)C[C@H]1CC[C@@H]1[C@@H]2C(=O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO.ClCCl

nearest known ligand 0.74

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
G6PD P11413 4/20 0.74
CYP3A4 P08684 4/20 0.73
GABRA1 P14867 5/20 0.55
GABRB2 P47870 5/20 0.55
GABRG2 P18507 3/20 0.55
GABRB3 P28472 3/20 0.55
GABRA2 P47869 3/20 0.55
CYP2C9 P11712 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
GLA P06280 1/20 0.55
HSD17B10 Q99714 6/20 0.52
LMNA P02545 2/20 0.52
ALDH1A1 P00352 2/20 0.52
NR3C1 P04150 2/20 0.52
SERPINA6 P08185 2/20 0.52
CYP2D6 P10635 1/20 0.52
TSHR P16473 1/20 0.52
SHBG P04278 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrocortisone SCHEMBL15669309 0.99 G6PD (0.73) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL21296378 0.97 G6PD (0.76) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1184193 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL4111245 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL193711 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1332665 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL1184192 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5610354 0.97 G6PD (0.79) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL11299557 0.96 G6PD (0.74) G6PDCYP3A4GABRA1GABRB2GABRG2
Tetrahydrocortisone SCHEMBL5139991 0.96 G6PD (0.77) G6PDCYP3A4GABRA1GABRB2GABRG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1784 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108424402-A Gamma glutamyl transpeptidase bioprobe and its preparation method and application 中国科学院化学研究所 2018-08-21 CN claimed
CN-102988997-A Drug-loaded nano particle and preparation method and application thereof NAT CT NANOSCIENCE NCNST CHINA 2013-03-27 CN claimed
CN-117580824-A Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2024-02-20 CN disclosed
CN-115246772-B Preparation method of isobutyryl methyl acetate 浙江科技学院 2024-02-02 CN disclosed
CN-116744928-A Quinolines modulating SERCA and their use for treating diseases 神经元公司 2023-09-12 CN disclosed
CN-116693514-A Aromatic ring substituted methoxy derivative and application thereof 上海璎黎药业有限公司 2023-09-05 CN disclosed
WO-2023115327-A1 PYRIDO RING COMPOUND, PREPARATION METHOD THEREFOR, INTERMEDIATE, COMPOSITION, AND APPLICATION 中国药科大学 2023-06-29 WO disclosed
EP-4182320-A1 INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS Nido Biosciences, Inc. (US) 2023-05-24 EP disclosed
CN-114539239-B AIE photosensitizer based on pyridinium salt and preparation method and application thereof 华南理工大学 2023-05-16 CN disclosed
CN-111479813-B Triazolobenzazepines as vasopressin V1A receptor antagonists 吉瑞工厂 2023-03-21 CN disclosed
CN-115734979-A Improved synthesis process for the production of ordered multiblock copolymers with controlled molecular weight distribution 于利希研究中心股份有限公司 2023-03-03 CN disclosed
CN-87102455-A Diphenyl ether derivatives pesticide compound 1988-01-27 CN disclosed
EP-0251093-A2 Production of antibody catalysts IGEN, INC. (US) 1988-01-07 EP disclosed
CN-87100191-A The hydroxy acid derivative of treatment diabetic complication 1987-09-09 CN disclosed
CN-86105140-A The 1-aryl pyrazole compound 1987-02-25 CN disclosed
CN-86104783-A The method for preparing beta-Lactam antibiotics 1987-02-04 CN disclosed
EP-0116836-A2 Process for producing polycarbonate resin particles MITSUBISHI KASEI CORPORATION (JP) 1984-08-29 EP disclosed
EP-0039967-A1 Solvate of amoxicillin, process for the preparation thereof and process for the preparation of injectable preparations from this solvate GIST-BROCADES N.V. (NL) 1981-11-18 EP disclosed
US-4277407-A LIGHT-SCREENING AGENTS IN COLOR PHOTOGRAPHY POLAROID CORPORATION (US) 1981-07-07 US disclosed
US-4189431-A CYCLIZATION OF POLYENINE TO POLYCYCLIC COMPOUND HAVING CYCLOPENTANO RING The Board of Trustees of Leland Stanford Junior University (US) 1980-02-19 US disclosed