SCHEMBL11301653

SCHEMBL11301653

CCCCC(CCC=CC#N)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 6/20 0.36
CYP3A4 P08684 5/20 0.36
CYP2C9 P11712 5/20 0.36
TSHR P16473 5/20 0.36
CYP2C19 P33261 5/20 0.36
CYP2D6 P10635 3/20 0.36
POLB P06746 2/20 0.35
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 1/20 0.34
SMN1; SMN2 Q16637 3/20 0.32
LMNA P02545 2/20 0.32
OPRM1 P35372 1/20 0.32
OPRD1 P41143 1/20 0.32
OPRK1 P41145 1/20 0.32
OPRL1 P41146 1/20 0.32
SIGMAR1 Q99720 1/20 0.31
MAPK1 P28482 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
KCNH2 Q12809 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11301651 1.00 CYP1A2 (0.36) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL11078121 0.86 LMNA (0.35) TSHRCYP2D6SMN1; SMN2LMNASIGMAR1
SCHEMBL11078122 0.86 LMNA (0.35) TSHRCYP2D6SMN1; SMN2LMNASIGMAR1
SCHEMBL5854238 0.81 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL5854233 0.81 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL6682502 0.79 POLB (0.47) POLBALDH1A1KDM4ELMNAOPRM1
SCHEMBL10502685 0.76 TSHR (0.43) TSHRPOLBALDH1A1KDM4ESMN1; SMN2
SCHEMBL17183788 0.76 TSHR (0.39) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL19511878 0.76 POLB (0.42) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL6682155 0.75 SIGMAR1 (0.46) POLBALDH1A1KDM4EOPRM1OPRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4136077-A REACTION PRODUCT OF OLEFINICALLY-UNSATURATED NITRILE AND A MONOOLEFINIC HYDROCARBON AS PLASTICIZER FOR CONJUGATED DIENE-UNSATURATED NITRILE RUBBER PHILLIPS PETROLEUM COMPANY (US) 1979-01-23 US claimed
US-4275237-A ETHYLENICALLY UNSATURATED POLYAMINE CURING AGENTS PHILIPS PETROLEUM COMPANY (US) 1981-06-23 US disclosed
US-4255352-A TANK REACTORS IN SERIES PHILLIPS PETROLEUM COMPANY (US) 1981-03-10 US disclosed
US-4218394-A FROM UNSATURATED NITRILES AND OLEFINS PHILLIPS PETROLEUM COMPANY (US) 1980-08-19 US disclosed
US-4217303-A UNSATURATED HYDROCARBON, ADDUCT, UNSATURATED DINITRILE, BY-PRODUCT INHIBITION PHILLIPS PETROLEUM COMPANY (US) 1980-08-12 US disclosed
US-4200586-A Inhibiting the carbon-carbon double bond isomerization of substituted or unsubstituted hydrocarbon compounds PHILLIPS PETROLEUM COMPANY (US) 1980-04-29 US disclosed
US-4195155-A Hydrogenated polynitrile mixture and use as epoxy hardener PHILLIPS PETROLEUM COMPANY (US) 1980-03-25 US disclosed
US-4136077-A REACTION PRODUCT OF OLEFINICALLY-UNSATURATED NITRILE AND A MONOOLEFINIC HYDROCARBON AS PLASTICIZER FOR CONJUGATED DIENE-UNSATURATED NITRILE RUBBER PHILLIPS PETROLEUM COMPANY (US) 1979-01-23 US disclosed
US-4117001-A TO RECOVER STARTING MATERIALS PHILLIPS PETROLEUM COMPANY (US) 1978-09-26 US disclosed
US-4117002-A PYROLYSIS OF HEAVIES FORMED IN PRODUCTION OF UNSATURATED DINITRILES PHILLIPS PETROLEUM COMPANY (US) 1978-09-26 US disclosed
US-3996262-A Method of promoting the reaction of unsaturated nitriles with olefins to produce unsaturated nitriles of increased carbon number PHILLIPS PETROLEUM COMPANY (US) 1976-12-07 US disclosed
US-3985786-A REACTING AN OLEFINICALLY UNSATURATED NITRILE, AN OLEFINIC HYDROCARBON AND THEIR MONOADDUCT IN WATER PHILLIPS PETROLEUM COMPANY (US) 1976-10-12 US disclosed