Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 8/20 | 0.71 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.71 |
| ▸ | PGR | P06401 | 7/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.71 |
| ▸ | AR | P10275 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 6/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11340199 | 0.85 | CYP3A4 (0.53) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL5490827 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL13769220 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL4694 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL13423594 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL21111542 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL5042122 | 0.83 | CYP3A4 (1.00) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| SCHEMBL11346248 | 0.83 | CYP3A4 (0.59) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| Flurandrenolide SCHEMBL3692151 | 0.82 | CYP3A4 (0.97) | CYP3A4NR3C1PGRHIF1AABCB11 | |
| SCHEMBL10028415 | 0.82 | PGR (0.85) | CYP3A4NR3C1PGRHIF1AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4273770-A | CORTICOIDS, ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1981-06-16 | — | — | US | disclosed |