Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flurandrenolide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 8/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 6/20 | 1.00 |
| ▸ | PGR | P06401 | 6/20 | 1.00 |
| ▸ | AR | P10275 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | HTR1A | P08908 | 1/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.70 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flurandrenolide SCHEMBL5042122 | 1.00 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL13423594 | 1.00 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL21111542 | 1.00 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL13769220 | 1.00 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL5490827 | 1.00 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL3692151 | 0.98 | CYP3A4 (0.97) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL10028415 | 0.92 | PGR (0.85) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL11862078 | 0.89 | CYP3A4 (0.80) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL11681436 | 0.88 | CYP3A4 (0.79) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL3655013 | 0.88 | CYP3A4 (0.79) | CYP3A4NR3C1HIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 19475 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260139030-A1 | CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION | SHATTUCK LABS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137656-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260137657-A1 | METHODS AND COMPOSITIONS FOR TREATING GLUCOCORTICOID EXCESS | SPARROW PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | claimed |
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-3717017-B1 | COVALENT ANESTHETIC-POLYMER CONJUGATES FOR PROLONGED LOCAL ANESTHESIA | CHILDRENS MEDICAL CT CORP (US) | 2026-02-25 | — | — | EP | claimed |
| US-20260027255-A1 | Cross-Linked Telechelic Polymer Compositions, Methods of Preparation Thereof, and Methods of Using Same | BETTY YU SKIN TECH ADVISORS LLC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4301343-B1 | PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME | TLC BIOPHARMACEUTICALS INC (US) | 2025-11-19 | — | — | EP | claimed |
| US-20250319104-A1 | MOISTURIZING CREAM FOR RADIATION DERMATITIS | PERRY ARTHUR W (US) | 2025-10-16 | — | — | US | claimed |
| US-12421281-B2 | Cyclosporine compositions and methods of use | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-09-23 | — | — | US | claimed |
| US-4346709-A | Drug delivery devices comprising erodible polymer and erosion rate modifier | ALZA CORPORATION (US) | 1982-08-31 | — | — | US | claimed |
| US-4343798-A | Topical antimicrobial anti-inflammatory compositions | THE PROCTER & GAMBLE COMPANY (US) | 1982-08-10 | — | — | US | claimed |
| EP-0055870-A1 | Pyridylmethyl esters of selected bio-affecting carboxylic acids, process for preparing and pharmaceutical composition comprising the same | MERCK & CO. INC. (US) | 1982-07-14 | — | — | EP | claimed |
| US-4333927-A | CORTICOSTEROID, PHOSPHATIDE, BUTYLHYDROXYANISOLE AND/OR BUTYLHYDROXYTOLUENE | MITSUBISHI CHEMICAL INDUSTRIES, LTD. (JP) | 1982-06-08 | — | — | US | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0033341-A1 | CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS | Research Corporation (US) | 1981-08-12 | — | — | EP | claimed |
| US-4283394-A | ANTICARCINOGENIC AGENTS | RESEARCH CORPORATION (US) | 1981-08-11 | — | — | US | claimed |
| US-4279900-A | ANTIINFLAMMATORY | INTREX RESEARCH CORPORATION (US) | 1981-07-21 | — | — | US | claimed |
| WO-1981000410-A1 | CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS | RESEARCH CORP (US) | 1981-02-19 | — | — | WO | claimed |
| US-4221787-A | Esteramide prodrugs of anti-inflammatory corticosteroids | INTERX RESEARCH CORPORATION (US) | 1980-09-09 | — | — | US | claimed |