Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flurandrenolide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 7/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.97 |
| ▸ | PGR | P06401 | 6/20 | 0.97 |
| ▸ | AR | P10275 | 3/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 5/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flurandrenolide SCHEMBL21111542 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL5042122 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL5490827 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL4694 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL13423594 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| Flurandrenolide SCHEMBL13769220 | 0.98 | CYP3A4 (1.00) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL10028415 | 0.90 | PGR (0.85) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL3655013 | 0.88 | CYP3A4 (0.79) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL11862078 | 0.88 | CYP3A4 (0.80) | CYP3A4NR3C1HIF1APGRAR | |
| SCHEMBL11681436 | 0.87 | CYP3A4 (0.79) | CYP3A4NR3C1HIF1APGRAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2293761-B1 | COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING MICROENCAPSULATED COLORANTS | TAGRA BIOTECHNOLOGIES LTD (IL) | 2017-02-01 | — | — | EP | claimed |
| CN-105263474-A | Corticosteroid compositions | TOLMAR INC | 2016-01-20 | — | — | CN | claimed |
| CN-102088946-A | Compositions for topical application comprising microencapsulated colorants | TAGRA BIOTECHNOLOGIES LTD | 2011-06-08 | — | — | CN | claimed |
| CN-101249095-A | Preparation of emulsifiable paste for containing decoloring agent, tretinoin and skinniness steroids | CHONGQING PHARM RES INST CO (CN) | 2008-08-27 | — | — | CN | claimed |
| CN-1063627-C | Compositions for regulating skin wrinkles and/or skin atrophy | RECHARDSON VISKS INC (US) | 2001-03-28 | — | — | CN | claimed |
| CN-1073859-A | Regulate the compositions of wrinkle of skin and/or atrophoderma | RICHARDSON VICKS INC (US) | 1993-07-07 | — | — | CN | claimed |
| CN-115836086-A | Methods of treating pemphigus disorders | 阿尔金克斯有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-113195596-B | Branched organosilicon compounds, methods of making branched organosilicon compounds, and compositions comprising branched organosilicon compounds | 美国陶氏有机硅公司 | 2023-02-28 | — | — | CN | disclosed |
| CN-113330054-B | Branched organosilicon compounds, methods of making, and copolymers formed therewith | 美国陶氏有机硅公司 | 2023-02-21 | — | — | CN | disclosed |
| CN-113348199-B | Branched organosilicon compounds, methods of making branched organosilicon compounds, and copolymers formed therewith | 美国陶氏有机硅公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-113166423-B | Branched organosilicon compounds, method for producing branched organosilicon compounds, and compositions containing branched organosilicon compounds | 美国陶氏有机硅公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-113348174-A | Branched organosilicon compounds, methods of making the branched organosilicon compounds, and related compositions | 美国陶氏有机硅公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-113348199-A | Branched organosilicon compounds, methods of making branched organosilicon compounds, and copolymers formed therewith | 美国陶氏有机硅公司 | 2021-09-03 | — | — | CN | disclosed |
| CN-101090751-A | Personal care compositions containing hydrophobically modified non-platelet particles | PROCTER & GAMBLE (US) | 2007-12-19 | — | — | CN | disclosed |
| CN-1738587-A | Topical skin care composition | HILL DERMACEUTICALS (US) | 2006-02-22 | — | — | CN | disclosed |
| CN-1132633-C | Pharmaceutical composition containing gelling agents in the form of alkylamides of di-and tri-carboxylic acids | PROCTER & GAMBLE (US) | 2003-12-31 | — | — | CN | disclosed |
| CN-1063627-C | Compositions for regulating skin wrinkles and/or skin atrophy | RECHARDSON VISKS INC (US) | 2001-03-28 | — | — | CN | disclosed |
| CN-1245435-A | Pharmaceutical compositions containing gellants in form of alkyl amides of di- and tri-carboxylic acids | PROCTER & GAMBLE (US) | 2000-02-23 | — | — | CN | disclosed |
| CN-1103316-A | Cyclodextrin and polymer based drug delivery system | INSITE VISION INC (US) | 1995-06-07 | — | — | CN | disclosed |
| CN-1073859-A | Regulate the compositions of wrinkle of skin and/or atrophoderma | RICHARDSON VICKS INC (US) | 1993-07-07 | — | — | CN | disclosed |