Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 12/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | AKT2 | P31751 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11310368 | 1.00 | INSR (0.44) | INSRADRB2RAB9AHTTPOLB | |
| SCHEMBL13646762 | 0.84 | INSR (0.47) | INSRRAB9AHTTPOLBNSD2 | |
| SCHEMBL10971186 | 0.83 | INSR (0.59) | INSRADRB2RAB9AHTTPOLB | |
| SCHEMBL10971188 | 0.83 | INSR (0.59) | INSRADRB2RAB9AHTTPOLB | |
| Bromide SCHEMBL11311515 | 0.79 | INSR (0.39) | INSRADRB2RAB9AHTTPOLB | |
| Bromide SCHEMBL10974485 | 0.74 | ALDH1A1 (0.43) | INSRADRB2RAB9AHTTPOLB | |
| SCHEMBL10974237 | 0.70 | INSR (0.46) | INSRADRB2RAB9AHTTPOLB | |
| SCHEMBL10974234 | 0.70 | INSR (0.46) | INSRADRB2RAB9AHTTPOLB | |
| Hydrochloric Acid SCHEMBL11515189 | 0.69 | INSR (0.59) | INSRADRB2RAB9AHTTPOLB | |
| Hydrochloric Acid SCHEMBL11515186 | 0.69 | INSR (0.59) | INSRADRB2RAB9AHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4306016-A | HETEROCYCLIC CYANINE DYE-LIKE NUCLEATING AGENTS | EASTMAN KODAK COMPANY (US) | 1981-12-15 | — | — | US | disclosed |