Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 4/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11311515 | 0.89 | INSR (0.39) | ALDH1A1MAPTHTTINSRADRB2 | |
| Bromide SCHEMBL10978688 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EMAPTHTTALOX12 | |
| Bromide SCHEMBL11310368 | 0.74 | INSR (0.44) | ALDH1A1MAPTHTTINSRADRB2 | |
| Bromide SCHEMBL11310366 | 0.74 | INSR (0.44) | ALDH1A1MAPTHTTINSRADRB2 | |
| SCHEMBL13646920 | 0.74 | KMT2A (0.51) | ALDH1A1KDM4EMAPTHTTALOX12 | |
| SCHEMBL10973513 | 0.73 | TSHR (0.40) | ALDH1A1KDM4EMAPTHTTINSR | |
| SCHEMBL10971188 | 0.72 | INSR (0.59) | ALDH1A1MAPTHTTALOX12INSR | |
| SCHEMBL10971186 | 0.72 | INSR (0.59) | ALDH1A1MAPTHTTALOX12INSR | |
| Bromide SCHEMBL11288193 | 0.72 | MAPT (0.41) | ALDH1A1KDM4EMAPTHTTALOX12 | |
| Hydrochloric Acid SCHEMBL11513903 | 0.69 | INSR (0.40) | ALDH1A1KDM4EMAPTHTTINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0050558-B1 | PHOTOGRAPHIC EMULSIONS AND ELEMENTS CAPABLE OF FORMING DIRECT-POSITIVE IMAGES | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1985-07-17 | — | — | EP | claimed |
| EP-0050558-A2 | Photographic emulsions and elements capable of forming direct-positive images | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1982-04-28 | — | — | EP | claimed |
| EP-0050558-A2 | Photographic emulsions and elements capable of forming direct-positive images | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1982-04-28 | — | — | EP | disclosed |
| US-4306016-A | HETEROCYCLIC CYANINE DYE-LIKE NUCLEATING AGENTS | EASTMAN KODAK COMPANY (US) | 1981-12-15 | — | — | US | disclosed |