SCHEMBL113113

SCHEMBL113113

Nc1nc2ccc(Cl)nc2s1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 3/20 0.40
MAPT P10636 2/20 0.40
AXL P30530 1/20 0.40
GFER P55789 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
GAA P10253 1/20 0.40
HTT P42858 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
SMN1; SMN2 Q16637 3/20 0.38
PI4KA P42356 3/20 0.37
PI4KB Q9UBF8 3/20 0.37
ALDH1A1 P00352 3/20 0.37
NPC1 O15118 2/20 0.37
SCN4A P35499 2/20 0.37
LMNA P02545 2/20 0.37
PIK3CA P42336 2/20 0.37
EPHX2 P34913 2/20 0.37
CYP3A4 P08684 2/20 0.37
KDM4E B2RXH2 1/20 0.37
PKM P14618 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30136461 1.00 RAB9A (0.40) RAB9AMAPTAXLGFERHRH3
SCHEMBL2666929 0.83 RAB9A (0.42) RAB9AMAPTAXLGFERGAA
SCHEMBL3710272 0.81 P2RY1 (0.41) RAB9ASMN1; SMN2ALDH1A1NPC1LMNA
SCHEMBL12042139 0.77 HRH3 (0.41) HRH3
SCHEMBL35211844 0.77 HRH3 (0.41) HRH3
SCHEMBL799228 0.75 RAB9A (0.41) RAB9AMAPTAXLGFERGAA
SCHEMBL30858903 0.75 AXL (0.48) RAB9AMAPTAXLGFERGAA
SCHEMBL558903 0.75 AXL (0.48) RAB9AMAPTAXLGFERGAA
SCHEMBL11999657 0.75 RAB9A (0.40) RAB9AMAPTAXLGFERGAA
SCHEMBL5533108 0.75 RAB9A (0.48) RAB9AMAPTAXLGFERGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 200 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4676480-A1 INHIBITORS OF DNA POLYMERASE THETA Breakpoint Therapeutics GmbH (DE) 2026-01-14 EP disclosed
US-20260007680-A1 Compounds and Their Use as PDE4 Activators MIRONID LIMITED (GB) 2026-01-08 US disclosed
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer ANIMA BIOTECH INC. (US) 2025-09-02 US disclosed
EP-4547672-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER Anima Biotech Inc. (US) 2025-05-07 EP disclosed
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER ANIMA BIOTECH INC. (US) 2025-04-24 US disclosed
US-20250099462-A1 Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor HUTCHISON MEDIPHARMA LTD (CN) 2025-03-27 US disclosed
US-12162895-B2 DNA polymerase theta inhibitor for treatment of cancer BREAKPOINT THERAPEUTICS GMBH (DE) 2024-12-10 US disclosed
US-12145945-B2 Compounds, compositions, and therapeutic uses thereof BREAKPOINT THERAPEUTICS GMBH (DE) 2024-11-19 US disclosed
US-20240336628-A1 NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF BREAKPOINT THERAPEUTICS GMBH (DE) 2024-10-10 US disclosed
US-20240327431-A1 DNA POLYMERASE THETA INHIBITOR FOR TREATMENT OF CANCER BREAKPOINT THERAPEUTICS GMBH (DE) 2024-10-03 US disclosed
US-7514439-B2 Oxime derivative and preparations thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 US disclosed
US-7514439-B2 Oxime derivative and preparations thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-04-07 US disclosed
US-7513916-B2 Agents for coloring keratin fibers THE PROCTER & GAMBLE COMPANY (US) 2009-04-07 US disclosed
WO-2008119734-A2 PROCESS FOR THE MANUFACTURE OF ORGANIC COMPOUNDS NOVARTIS AG (CH) 2008-10-09 WO disclosed
US-20080132479-A1 Oxime Derivative and Preparations Thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-06-05 US disclosed
US-20080132479-A1 Oxime Derivative and Preparations Thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-06-05 US disclosed
WO-2007097930-A1 AGENTS FOR COLORING KERATIN FIBERS THE PROCTER & GAMBLE COMPANY (US) 2007-08-30 WO disclosed
US-20070199160-A1 Agents for coloring keratin fibers THE PROCTER & GAMBLE COMPANY 2007-08-30 US disclosed
EP-1825883-A1 Agents for coloring keratin fibers Wella Aktiengesellschaft (DE) 2007-08-29 EP disclosed
EP-1820537-A1 Agents for coloring keratin fibers Wella Aktiengesellschaft (DE) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12162895-B2 DNA polymerase theta inhibitor for treatment of cancer POLQ, POLB, POLH RAB9A 3225/4885MAPT 1209/4885AXL 4552/4885
US-20260007680-A1 Compounds and Their Use as PDE4 Activators PDE4A, PDE7A, PDE4B RAB9A 1082/4885MAPT 4801/4885AXL 4128/4885
US-20250129100-A1 C-MYC MRNA TRANSLATION MODULATORS AND USES THEREOF IN THE TREATMENT OF CANCER MYC, MYCBP, MYCBP2 RAB9A 2519/4885MAPT 3215/4885AXL 3982/4885
US-20240336628-A1 NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF POLQ, POLK, POLB RAB9A 1764/4885MAPT 1489/4885AXL 4734/4885
US-20080132479-A1 Oxime Derivative and Preparations Thereof GCK, KHK, GCKR RAB9A 4012/4885MAPT 4489/4885AXL 354/4885
US-20240327431-A1 DNA POLYMERASE THETA INHIBITOR FOR TREATMENT OF CANCER POLQ, POLB, POLH RAB9A 3225/4885MAPT 1209/4885AXL 4552/4885
US-12404283-B2 c-MYC mRNA translation modulators and uses thereof in the treatment of cancer MYC, MYCBP, MYCBP2 RAB9A 2519/4885MAPT 3215/4885AXL 3982/4885
US-12145945-B2 Compounds, compositions, and therapeutic uses thereof POLQ, POLK, POLB RAB9A 2158/4885MAPT 1441/4885AXL 4630/4885
US-20250099462-A1 Certain Triazolopyridines and Triazolopyrazines, Compositions Thereof and Methods of Use Therefor KCNJ11, NISCH, CYP4Z1 RAB9A 4795/4885MAPT 3267/4885AXL 4163/4885
US-20070199160-A1 Agents for coloring keratin fibers KRT18, IK, KRTCAP2 RAB9A 3182/4885MAPT 781/4885AXL 3511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.