Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13943144 | 0.79 | IDO1 (0.37) | IDO1ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL11434480 | 0.69 | ALDH1A1 (0.40) | IDO1ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL22805 | 0.67 | MAPT (0.46) | IDO1ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL30989896 | 0.66 | — | — | |
| SCHEMBL5164437 | 0.65 | PABPC1 (0.46) | ALDH1A1MAPTMEN1USP2GAA | |
| SCHEMBL11422063 | 0.65 | MAPT (0.42) | ALDH1A1MAPTRAB9ANPSR1MAPK1 | |
| Duroquinone SCHEMBL11408085 | 0.62 | DDAH1 (0.36) | IDO1ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL11421145 | 0.62 | DUSP3 (0.31) | — | |
| SCHEMBL14507720 | 0.60 | ALDH1A1 (0.44) | IDO1ALDH1A1MAPTRAB9ANPSR1 | |
| SCHEMBL7971367 | 0.60 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0753298-B2 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO CO (JP) | 2011-02-16 | — | — | EP | disclosed |
| CN-1089584-C | Treatment for arteriosclerosis and vitiligoidea | SANKYO CO (JP) | 2002-08-28 | — | — | CN | disclosed |
| EP-0753298-B1 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO CO (JP) | 2001-11-21 | — | — | EP | disclosed |
| EP-0745600-B1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-10-24 | — | — | EP | disclosed |
| CN-1066729-C | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-06-06 | — | — | CN | disclosed |
| US-6159997-A | Treatment of arteriosclerosis and xanthoma | SANKYO COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |
| US-5886014-A | TREATMENT AND/OR PROPHYLAXIS OF A VARIETY OF DISORDERS, INCLUDING HYPERLIPEMIA, HYPERGLYCEMIA, OBESITY, IMPAIRED GLUCOSE TOLERANCE (IGT), INSULIN RESISTANCE AND DIABETIC COMPLICATIONS | SANKYO COMPANY, LIMITED (JP) | 1999-03-23 | — | — | US | disclosed |
| US-5798375-A | ADMINISTERING TO THE PATIENT PREVASTATIN A HYDROXY-3-METHYL-GLUTARYL/3-/ COENZYME A REDUCTASE INHIBITOR AND A INSULIN SENSITIZER TROGLITAZONE | SANKYO COMPANY, LIMITED (JP) | 1998-08-25 | — | — | US | disclosed |
| US-5674876-A | ANTIPROLIFERATIVE,-CARCINOGENIC AND -TUMOR AGENTS; SKIN DISORDERS; FREE RADICAL SCAVENGERS | RESEARCH DEVELOPMENT FOUNDATION (US) | 1997-10-07 | — | — | US | disclosed |
| CN-1157288-A | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 1997-08-20 | — | — | CN | disclosed |
| CN-1148492-A | Treatment for arteriosclerosis and vitiligoidea | SANKYO CO (JP) | 1997-04-30 | — | — | CN | disclosed |
| EP-0753298-A1 | Synergistic combination comprising an insulin sensitizer and a HMG-CoA reductase inhibitor for treating arteriosclerosis | SANKYO COMPANY LIMITED (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0745600-A1 | Benzimidazole derivatives, their preparation and their therapeutic use | SANKYO COMPANY LIMITED (JP) | 1996-12-04 | — | — | EP | disclosed |
| WO-1996022089-A1 | p-HETEROATOM-SUBSTITUTED PHENOLS AND USES THEREOF | RESEARCH DEVELOPMENT FOUNDATION (US) | 1996-07-25 | — | — | WO | disclosed |
| US-4242277-A | STABILIZATION OF NITROUS ACID BY AN ORGANIC ACID AND ANOTHER ACID TO OBTAIN BENZOQUINONE OXIMES | MITSUBISHI PETROCHEMICAL COMPANY, LIMITED (JP) | 1980-12-30 | — | — | US | disclosed |
| US-4237326-A | SOLUTION OF METHYLATED BENZOQUINONE-4-OXIME | MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) | 1980-12-02 | — | — | US | disclosed |