Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314723 | 0.89 | SMN1; SMN2 (0.43) | HDAC6NPSR1POLBTMEM97SIGMAR1 | |
| SCHEMBL11229708 | 0.87 | GAA (0.45) | HDAC6NPSR1POLBHTT | |
| SCHEMBL11311686 | 0.87 | PTGIR (0.41) | HDAC6NPSR1PTGIRPOLBSMN1; SMN2 | |
| SCHEMBL11220472 | 0.86 | NPSR1 (0.47) | NPSR1PTGIRITGB3ITGB1ITGAV | |
| SCHEMBL11220562 | 0.84 | HTT (0.44) | HDAC6NPSR1PTGIRTMEM97SIGMAR1 | |
| SCHEMBL11314738 | 0.83 | HSP90AA1 (0.42) | HDAC6NPSR1POLBSMN1; SMN2KDM4E | |
| SCHEMBL11321942 | 0.83 | PTGIR (0.39) | HDAC6NPSR1PTGIRSMN1; SMN2KDM4E | |
| SCHEMBL11262824 | 0.83 | HDAC6 (0.41) | HDAC6NPSR1POLBTMEM97SIGMAR1 | |
| SCHEMBL11116763 | 0.82 | HDAC6 (0.43) | HDAC6NPSR1PTGIRSMN1; SMN2KDM4E | |
| SCHEMBL11221883 | 0.81 | HDAC6 (0.38) | HDAC6NPSR1POLBTMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4250183-A | GASTOINTESTINAL DISORDERS; DISEASES OF THE PANCREAS, GALL BLADDER, AND LIVER | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-02-10 | — | — | US | disclosed |
| EP-0003056-A1 | N-substituted omega-aminoalkanoyl-omega-aminoalkanecarboxylic acids, their application and process for their preparation, and medicines containing these compounds | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1979-07-25 | — | — | EP | disclosed |