Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.56 |
| ▸ | HSPA5 | P11021 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11310643 | 0.86 | LMNA (0.57) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL23804604 | 0.85 | LMNA (0.59) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL7876872 | 0.85 | LMNA (0.59) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL7868173 | 0.85 | LMNA (0.56) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL1107000 | 0.84 | ADORA2A (0.68) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| Bromide SCHEMBL11310364 | 0.82 | LMNA (0.58) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL7873351 | 0.81 | FFAR2 (0.60) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL27228868 | 0.81 | FFAR2 (0.60) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL27891187 | 0.81 | FFAR2 (0.62) | LMNAFFAR2TSHRHSPA9HSPA5 | |
| SCHEMBL6056907 | 0.81 | HSPA5 (0.57) | LMNAFFAR2TSHRHSPA9HSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4305949-A | ANTIINFLAMMATORY AGENTS AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1981-12-15 | — | — | US | disclosed |
| EP-0005070-B1 | N-(2-THIAZOLYL)AMIDES AND THEIR USE AS ANTI-INFLAMMATORY AND IMMUNOREGULATORY AGENTS | PFIZER INC. (US) | 1981-12-09 | — | — | EP | disclosed |
| US-4217355-A | N-(I-THIAZOLYL)-A-(SUBSTITUTED AMINO)AMIDES, ANTIINFLAMMATORY, IMMUNOREGULATIVE | PFIZER INC. (US) | 1980-08-12 | — | — | US | disclosed |
| EP-0005070-A2 | N-(2-thiazolyl)amides and their use as anti-inflammatory and immunoregulatory agents | PFIZER INC. (US) | 1979-10-31 | — | — | EP | disclosed |